New York, USA – July 29, 2022 – Creative Biogene, a scientists-founded and scientists-driven leading biotechnological company, focuses on developing high quality products and services to accelerate the research pace in the field of biomedical development, industrial synthetic application and preclinical drug discovery. Recently, Creative Biogene announced the release of its microRNA agomir synthesis services which can be applied to support new drug research with cutting-edge chemical synthesis technology.
Creative Biogene is committed to providing superior miRNA products and comprehensive services to facilitate and simplify miRNA research. Creative Biogene provides agomir/antagomir synthesis services covering all human, mouse and rat miRNAs currently in miRBase. They are synthetic RNA molecules developed for the study of miRNA function in vivo.
Creative Biogene’s micro DOWN™ miRNA antagomirs are single-stranded miRNA inhibitors that exert chemical modifications by effectively blocking miRNA regulation of target gene expression. The chain of antagomir has 2 phosphorothioates at the 5′ end, 4 phosphorothioates at the 3′ end, a cholesterol group, and a full-length nucleotide 2′-methoxy modification. The micro DOWN™ miRNA antagomir appears to be significantly more stable than miRNA inhibitors. It exhibits enhanced cellular uptake, stability, and regulatory activity and is recommended for in vitro and in vivo miRNA functional studies.
Creative Biogene’s micro UP™ miRNA agomirs are designed to mimic mature miRNAs and chemically modified to increase their stability and activity. They are recommended for in vitro and in vivo miRNA functional studies.
MicroRNAs incompletely pair with the target messenger RNAs (mRNAs) of protein-coding genes and regulate their expression transcriptionally or post-transcriptionally to participate in key biological processes, including development, differentiation, apoptosis, and proliferation. Creative Biogene’s miRNAs Agomir and Antagomir can be efficiently enriched in target cells to achieve specific and stable interference, so Agomir/Antagomir transfection of cells and animal injection are two major research applications. miRNA Agomir/Antagomir are for research use only, but these advanced products still have practical implications for research in clinical trials, cancer therapy, and gene therapy, as miRNAs are presumed to regulate one-third of human genes.
“Our team has pioneered the development of microRNA research and diagnostic tools with leading service. We are committed to opening new avenues to meet all your needs for miRNA agomir/antagomir synthesis.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “Our experienced team can always provide professional service according to your needs.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.